[Remote] Senior Director, Trade & Channel Operations

Note: The job is a remote job and is open to candidates in USA. Amylyx Pharmaceuticals is a clinical-stage company focused on treating diseases with high unmet needs. The Senior Director, Trade & Channel Operations will be responsible for building the U.S. distribution and channel model in preparation for a commercial launch, architecting the distribution strategy, and ensuring operational alignment across various functions.

Responsibilities

• Design and build Amylyx’s U.S. distribution model across specialty pharmacy, specialty distributor, and 3PL channels to support product launch
• Lead contracting strategy for specialty pharmacies and distributors, including negotiating distribution and service agreements, fee schedules, data requirements, and service levels
• Integrate distribution channels with service programs and field initiatives to enable a seamless customer experience
• Collaborate with Supply Chain and Finance to support 3PL operations, including order‑to‑cash processes, inventory management, data exchange, shipping, returns, and chargeback management
• Establish and manage noncommercial and free‑goods pharmacy operations
• Forecast and model channel performance, assess specialty pharmacy throughput, and provide recommendations to ensure timely, reliable patient access
• Develop distribution analytics including inventory visibility, service metrics, dispense data, time to therapy, and partner scorecards; lead specialty pharmacy QBRs
• Partner cross‑functionally with Supply Chain, Quality, Compliance, Legal, Finance, Patient Services, and Commercial Operations to ensure operational alignment and launch readiness
• Serve as a senior leader within Market Access, contributing to launch planning, forecasting, patient access workflows, and overall distribution strategy
• Continuously optimize post‑launch distribution operations by driving root‑cause remediation, vendor KPI management, and process improvements informed by field and service feedback

Skills

• Bachelor's degree required
• 12+ years of experience in biopharmaceutical trade and distribution, including leadership of specialty pharmacy and distributor channel networks
• Prior product launch experience in the US market
• Experience designing and implementing channel strategies for product launches
• Proven ability to assess, manage, and influence channel partner performance to contractual expectations
• Hands‑on experience with 3PL operations, serialization, state licensing, and compliant distribution processes
• Demonstrated strength in contract negotiation, vendor management, and commercial channel operations
• Deep understanding of payer reimbursement, hub/patient support integration, channel economics, and order‑to‑cash workflows
• Proven leadership experience, including managing large pharmaceutical vendors, with demonstrated people management skills
• Excellent communication, vendor management, analytical, and project execution capabilities

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